STEPHEN L. BOEHM II, Ph.D. Curriculum Vitae Current Position: Associate Professor Psychobiology of Addictions Department of Psychology Indiana University – Purdue University Indianapolis Address: 402 North Blackford Street Science Building, LD126 D Psychology Indianapolis, IN 46202-3275 Phone: 317-274-6927 Fax: 317-274-6756 Email: slboehm@iupui.edu Education: Postdoctoral, University of Texas at Austin, 2002-2005. Behavioral and Molecular Pharmacology. Ph.D., Oregon Health & Science University, Portland, 1996-2002. Behavioral Neuroscience. B. A., University of Northern Colorado, Greeley, 1990-1996. Psychology. Research Interests: Age- and genotype-specific differences in neurobehavioral sensitivity to alcohol Research Experience: 2009-present, Associate Professor, Psychobiology of Addictions, Department of Psychology, Indiana University - Purdue University Indianapolis 2005-2009, Assistant Professor, Behavioral Neuroscience, Department of Psychology, Binghamton University • mRNA expression in mouse brain using real-time PCR 2002-2005, Postdoctoral Fellow, University of Texas at Austin, modulation of GABAA receptor function, R. Adron Harris, Ph.D. (supervisor). • whole cell and patch-clamp recordings from mouse ventral tegmental area dopamine neurons (under the direction of Dr. Hitoshi Morikawa). • GABAA receptor/complex modulation of chloride flux in synaptosomes. • GABAA receptor binding assay. • loss of the righting reflex test for sedative hypnotic drugs. • acoustic startle response. • animal models of alcohol reinforcement including ethanol conditioned place preference and ethanol preference drinking. 1998-2002, Graduate Research Assistant, Oregon Health & Science University, genetics of alcohol-related phenotypes in mice, Tamara Phillips, Ph.D. (supervisor). • stereotaxic placement and microinjection of drug into specific brain regions in mice, including histological analysis. • quantitative GABAB receptor autoradiography. • detailed analysis of locomotor behavior. • animal models of anxiety, including the elevated plus maze and light-dark box. • corticosterone radioimmunoassay. • GABAB receptor binding assay. 1996-1998, Graduate Research Assistant, Oregon Health Sciences University, genetics of alcohol-related phenotypes in mice, John Crabbe, Ph.D. (supervisor). Stephen L. Boehm II 2 • animal models of motor incoordination including the dowel, rotarod, screen, and grid tests. • basic molecular genetic techniques including PCR. 1992-96, Undergraduate Research Assistant, University of Northern Colorado, genetics of fetal alcohol effects in mice, David Gilliam, Ph.D. (supervisor). • genetic animal models of Fetal Alcohol Syndrome. • behavioral teratology, including the water maze. • classical teratology including soft-tissue and skeletal examination. Awards: 2008 National Institutes of Health Pediatric Loan Repayment Program Award 2006 International Society for Biomedical Research on Alcoholism Travel Award, Sydney, Australia 2004 National Institutes of Health Clinical Loan Repayment Program Award, renewal 2004 International Society for Biomedical Research on Alcoholism Travel Award, Heidelberg, Germany 2003 International Behavioral and Neural Genetics Society travel award, New Orleans, LA 2003 Research Society on Alcoholism Student Merit Award, Ft. Lauderdale, Florida 2002 National Institutes of Health Clinical Loan Repayment Program Award 2002 Institutional National Research Service Award, Postdoctoral Fellowship (T32AA07471-15) 2001 Biomedical Graduate Research Recognition Award, Research Society on Alcoholism 2001 Research Society on Alcoholism Student Merit Award, Montreal, Quebec, Canada 2000 Research Society on Alcoholism Student Merit Award, Denver, Colorado 2000 Oregon Health Sciences University Dean’s Travel Funds Award to attend the Research Society on Alcoholism meeting in Denver, Colorado 1998 Oregon Health Sciences University Dean’s Travel Funds Award to attend the Society for Neuroscience meeting in Los Angeles, California 1998 Oregon Health Sciences University N.L. Tartar Research Fellowship 1998 Research Society on Alcoholism Student Merit Award, Hilton Head, South Carolina 1997 Travel award to attend the Third French-American Summer School on Neurobehavioral Genetics, Orleans, France 1996 Institutional National Research Service Award, Predoctoral Fellowship (T32AA07468) 1996 University of Northern Colorado Departmental Scholar, Psychology 1995 Research Society on Alcoholism Student Merit Award, Steamboat Springs, Colorado 1995 University of Northern Colorado Academic Enrichment Grant, to attend annual meeting in Steamboat Springs, Colorado 1995 University of Northern Colorado Departmental Scholar, Psychology 1994 University of Northern Colorado, Lambda Sigma Tau, Chemistry Honor Society grant 1994 University of Northern Colorado Academic Enrichment Grant to attend the Colorado-Wyoming Academy of Science meeting in Durango, Colorado 1993 University of Northern Colorado Dean’s List of Academic Distinction 1993 University of Northern Colorado Eleanor S. and Alma J. Dickerson Merit Scholarship Professional Affiliations: 2009-present Member of the International Society for Developmental Psychobiology 1999-present Member of the International Society for Biomedical Research on Alcoholism 1998-present Member of the Society for Neuroscience 1998-present Member of the Research Society on Alcoholism Publications: 1. Boehm II SL, Lundahl KR, Caldwell J, Gilliam DM (1997) Ethanol teratogenesis in the C57BL/J, DBA/2J, and A/J inbred mouse strains. Alcohol, 4:389-395. 2. Boehm II SL, Schafer GL, Phillips TJ, Browman KE, Crabbe, JC (2000) Sensitivity to ethanol-induced motor incoordination in 5-HT1B receptor null mutant mice is task dependent: Implications for behavioral assessment of genetically altered mice. Behavioral Neuroscience, 114:401-409. Stephen L. Boehm II 3 3. Boehm II SL, Crabbe JC, Phillips TJ (2000) Sensitivity to ethanol-induced motor incoordination in FAST and SLOW selectively bred mice. Pharmacology, Biochemistry, and Behavior, 66:241-247. 4. Rustay N, Boehm II SL, Schafer GL, Browman KE, Erwin VG, Crabbe JC (2001) Sensitivity and tolerance to ethanol-induced incoordination and hypothermia in HAFT and LAFT mice. Pharmacology, Biochemistry, and Behavior, 70:167-174. 5. Boehm II SL, Reed CL, McKinnon CS, Phillips TJ (2002) Shared genes influence sensitivity to the effects of ethanol on locomotor behavior and anxiety-like behaviors, and the stress axis. Psychopharmacology, 161:54-63. 6. Boehm II SL, Piercy MM, Bergstrom HC, Phillips TJ (2002) Ventral tegmental area region governs GABAB receptor modulation of ethanol-stimulated activity in mice. Neuroscience, 115:185-200. 7. Wahlsten D, Metten P, Phillips TJ, Boehm II SL, Burkhart-Kasch S, Dorow J, Doerksen S, Downing C, Fogarty J, Rodd-Henricks K, Hen R, McKinnon CS, Merrill CM, Nolte C, Schalomon M, Schlumbohm JR, Sibert JR, Wenger CD, Dudek BC, Crabbe JC (2003) Different data from different labs: Lessons from studies of gene-environment interaction. Journal of Neurobiology, 54:283-311. 8. Boehm II SL, Peden L, Chang R, Harris RA, Blednov YA (2003) Deletion of the fyn-kinase gene alters behavioral sensitivity to alcohol. Alcoholism: Clinical and Experimental Research, 27:1033-1040. 9. Boehm II SL, Peden L, Harris RA, Blednov YA (2004) Fyn-deficient mice exhibit altered sensitivity to GABAergic drugs: Dependence on the β2/β3 receptor subunits. Journal of Pharmacology and Experimental Therapeutics, 309:1154-1159. 10. Diaz LM, Maiya R, Han Y, Scott H, Boehm II SL, Bergeson SE, Mayfield RD, Morrisett RA (2004) Sindbis viral-mediated expression of eGFP-dopamine D1 receptors in situ. Journal of Neuroscience Methods, 139:25-31. 11. Boehm II SL, Ponomarev I, Jennings AW, Whiting PJ, Rosahl TW, Garrett EM, Blednov YA, Harris RA (2004) γ-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol action. Biochemical Pharmacology, 68:1581-1602. 12. Boehm II SL, Peden L, Jennings AW, Kojima N, Harris RA, Blednov YA (2004) Over-expression of the fynkinase gene reduces hypnotic sensitivity to ethanol. Neuroscience Letters, 372:6-11. 13. Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm II SL, Homanics GE, Berman A, Lodowski KH, Bergeson SE, Harris RA (2006) Transcriptional signatures of cellular plasticity in mice lacking the α1 subunit of GABAA receptors. Journal of Neuroscience, 26:5673- 5683. 14. Boehm II SL, Homanics GE, Blednov YA, Harris RA (2006) δ-Subunit Containing GABAA Receptor Knockout Mice are Less Sensitive to the Actions of THIP. European Journal of Pharmacology, 541:158- 162. 15. Borghese CM, Elsen FP, Werner DF, Topf N, Baron NV, Henderson LA, Boehm II SL, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL (2006) Characterization of an isoflurane insensitive mutant GABAA receptor α1 subunit with near normal affinity for GABA in heterologous systems and knockin mice. Journal of Pharmacology and Experimental Therapeutics, 319:208-218. 16. Boehm II SL, Ponomarev I, Blednov YA, Harris Ra (2006) From gene to behavior and back again: New perspectives on GABAA receptor subunit selectivity of alcohol actions. Advances in Pharmacology, 54:171- 203. 17. Blednov YA, Cravatt BF, Boehm II SL, Walker D, Harris RA (2007) Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology, 32:1570-1582. 18. Moore EM, Serio KM, Goldfarb KJ, Stepanovska S, Linsenbardt DN, Boehm II SL (2007) GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. Pharmacology, Biochemistry and Behavior, 88:105-113. 19. Pautassi RM, Nizhnikov M, Molina JC, Boehm II SL, Spear N (2007) Ethanol’s devaluation of aversive stimuli not mimicked by midazolam. Alcohol, 41:421-431. 20. Boehm II SL, Goldfarb KJ, Serio KM, Moore, EM, Linsenbardt DN (2008) Does context influence the duration of locomotor sensitization to ethanol in female DBA/2J mice? Psychopharmacology, 197:191-201. 21. Mulligan MK, Ponomarev I, Boehm II SL, Owen JA, Levin PS, Berman AE, Blednov YA, Crabbe JC, Williams RW, Miles MF, Bergeson SE (2008) Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains. Genes, Brain and Behavior, 7:677-689. Stephen L. Boehm II 4 22. Boehm II SL, Moore EM, Walsh CD, Gross C, Cavelli A, Gigante E, Linsenbardt DN DN (2008) Using Drinking in the Dark to model prenatal binge-like exposure to ethanol in C57BL/6J mice. Developmental Psychobiology, 50:566-578. 23. Linsenbardt DN, Moore EM Gross CD, Goldfarb KJ, Blackman LC, Boehm II SL (2009) Sensitivity and tolerance to the hypnotic and ataxic effects of ethanol in adolescent and adult C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research, 33:1-13. 24. Moore EM, Boehm II SL (2009) Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces ethanol intake in male C57BL/6J mice. Behavioral Neuroscience, in press. 25. Linsenbardt DN, Boehm II SL (2009) Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice: Involvement of the posterior ventral tegmental area. Neuroscience, submitted. 26. Moore EM, Linsenbardt DN, Blackman LC, Boehm II SL (2009) Ontogenetic differences in adolescent and adult C57BL/6J and DBA/2J mice: Anxiety-like, locomotor, and consummatory behaviors. Developmental Psychobiology, submitted. 27. Linsenbardt DN, DN, Boehm II SL (2009) Ethanol-induced locomotor sensitization in DBA/2J mice is associated with alterations in GABAA subunit gene expression and behavioral sensitivity to GABAA acting drugs. Journal of Pharmacology and Experimental Therapeutics, submitted. Book Chapters and Reviews: 1. Boehm II SL, Valenzuela CF, Harris RA Alcohol: Neurobiology. In Substance Abuse: A comprehensive textbook, Fourth Edition, Lowinson, Ruiz, Millman, and Langrod Eds. Williams and Wilkins, Baltimore MD, 2005:121-151. Poster Presentations: 1. Boehm II S, Lundahl K, Caldwell J, Gilliam D (1994) Ethanol teratogenesis in C57BL/6J, A/J, and DBA/2J mice: Maternal effects. The Journal of the Colorado-Wyoming Academy of Science, 26:32. 2. Caldwell J, Lundahl K, Boehm II S, Gilliam D (1994) Alcohol exposure in three inbred mouse strains: Litter measures. The Journal of the Colorado-Wyoming Academy of Science, 26:32. 3. Lundahl K, Boehm II S, Caldwell J, Gilliam D (1994) Skeletal and soft-tissue malformations among three inbred mouse strains. The Journal of the Colorado-Wyoming Academy of Science, 26:32. 4. Boehm II S, Caldwell J, Gilliam D (1995) Ethanol clearance in pregnant B6, D2, and A mice. Alcoholism: Clinical and Experimental Research, 19:52A. 5. Buck KJ, Lischka T, Boehm S, Cross S (1997) Detection of a GABAA receptor α6 subunit sequence variant in DBA/2 and C57BL/6 inbred strains of mice. Alcoholism: Clinical and Experimental Research, 21:73A. 6. Crabbe JC, Schafer GL, Boehm S (1997) Ethanol ataxia: effects of deletion of the serotonin 5-HT1B receptor depend upon the specific behavioral endpoint. Alcoholism: Clinical and Experimental Research, 21:14A. 7. Crabbe JC, Phillips TJ, Schafer GL, Boehm II S (1997) Ethanol ataxia in null mutant mice missing the serotonin 5-HT1B receptor. Society for Neuroscience Abstracts, 23:729.9. 8. Finn DA, Patterson B, Douglass AD, Mair JJ, Boehm S, Griesar W, Mitchell SR, Washington S, Gionet S, Gallaher EJ (1998) Genetic analysis of neuroactive steroid sensitivity. Alcoholism: Clinical and Experimental Research, 22:44A. 9. Boehm II SL, Schafer GL, Metten P, Crabbe JC, Erwin VG (1998) Sensitivity and tolerance to ethanolinduced ataxia and hypothermia in the high and low acute functional tolerance selected lines. Alcoholism: Clinical and Experimental Research, 22:100A. 10. Buck KJ, Hood HM, Boehm SL, Lischka TR (1998) Analysis of a GABAA receptor variant in mice prone or resistant to physical dependence on alcohol. Alcoholism: Clinical and Experimental Research, 22:157A. 11. Boehm II SL, Phillips TJ, Metten P, Crabbe JC (1998) Sensitivity to ethanol ataxia in mouse lines selected for high and low ethanol-induced locomotor activation. Society for Neuroscience Abstracts, 24:292.5. 12. Boehm II SL, Phillips TJ (1999) FAST and SLOW selectively bred mice are differentially sensitive to ethanol’s anxiolytic effects. Society for Neuroscience Abstracts, 578:634.6. 13. Boehm II SL, Reed CL, Phillips TJ (2000) Ethanol’s anxiolytic effects in the FAST and SLOW selectively bred mouse lines. Alcoholism: Clinical and Experimental Research, 24:95A. Stephen L. Boehm II 5 14. Boehm II SL, Phillips TJ (2000) Injection of baclofen into the ventral tegmental area of mice selected for extreme sensitivity to ethanol-induced stimulation. Society for Neuroscience Abstracts, 26:673.15. 15. Boehm II SL, Bergstrom HC, Phillips TJ (2001) Effects of intra-VTA baclofen on ethanol-stimulated activity depend on region of injection. Alcoholism: Clinical and Experimental Research, 25:116A. 16. Boehm II SL, Chang R, Peden L, Blednov YA, Harris RA. Evidence for altered GABAA receptor function in fyn-kinase null mutant mice. Society for Neuroscience Satellite Meeting: GABAA Receptors in Cellular and Network Excitability, October, 2002. 17. Maiya R, Diaz LM, Alcantara AA, Bergeson SE, Boehm SL, Croyle M, Levin PS, Scott H, Morrisett RA, Mayfield RD (2003) In vivo viral delivery of GFP-labeled dopamine transporter in mouse brain. Alcoholism: Clinical and Experimental Research, 27:89A. 18. Diaz LM, Maiya R, Boehm SL, Scott H, Bergeson SE, Mayfield RD, Morrisett RA (2003) Sindbis viral deliver of eGFP labeled dopamine D1 receptors into primary cultured neurons, brain slice culture and in vivo. Alcoholism: Clinical and Experimental Research, 27:93A. 19. Diaz LM, Maiya R, Boehm SL, Scott H, Bergeson SE (2003). Sindbis viral delivery of eGFP-dopamine D1 receptors into native neuronal preparations. Program No. 160.14. 2003 Abstract Viewer and Itinerary Planner, New Orleans, LA: Society for Neuroscience, online. 20. Boehm II SL, Jennings AW, Blednov YA, Harris RA. The behavioral actions of alcohol exhibit GABAA receptor subunit specificity: α2 and α5 receptor subunits. International Behavioral and Neural Genetics Society, New Orleans, LA, November 2003. 21. Boehm II SL, Peden L, Kojima N, Harris RA (2004). Over-expression of the fyn-kinase gene alters behavioral sensitivity to ethanol. Alcoholism: Clinical and Experimental Research, 28:3.a.20. 22. Boehm II SL, Jennings AW, Whiting P, Rosahl T, Garrett E, Blednov YA, Harris RA (2004). The behavioral actions of alcohol exhibit GABAA receptor subunit specificity: Evidence from α2 and α5 knockout mice. Alcoholism: Clinical and Experimental Research, 28:3.a.21. 23. Ponomarev I, Schafer GL, Blednov YA, Harnett MT, Morikawa H, Maiya RD, Boehm II SL, Datta RK, Ryabinin AE, Harris RA (2005). GABAA receptors and ethanol-induced locomotor activation: What can gene expression profiles in α1 subunit-deficient mice tell us? Alcoholism: Clinical and Experimental Research, 29:49A. 24. Mulligan MK, Boehm II SL, Ponomarev I, Levin PS, Bergeson SE (2005). Genetic and behavioral analysis of disparate alcohol preference in two closely related inbred strains of C57BL/6 mice. Alcoholism: Clinical and Experimental Research, 29:91A. 25. Mulligan MK, Boehm II SL, Ponomarev I, Levin PS, Blednov YA, Bergeson SE (2005). Expression analysis comparison of two mouse models of alcohol preference. Program No. 560.21. 2005 Abstract Viewer and Itinerary Planner, Washington, DC: Society for Neuroscience, online. 26. Nizhnikov ME, Molina JC, Boehm II SL, Spear NE (2006) Effects of ethanol and midazolam on ultra sound emissions in the isolated infant rat pup. Alcoholism: Clinical and Experimental Research, 30:23A. 27. Moore E, Boehm II SL (2006) Baclofen enhances excessive alcohol intake in mice. Alcoholism: Clinical and Experimental Research, 30:138A. 28. Boehm II SL (2006) Duration of locomotor sensitization to ethanol in DBA/2J mice. International Society for Biomedical Research on Alcoholism meeting, Sydney, Australia. 29. Moore EM, Linsenbardt DN, Boehm II SL (2007). Sensitivity and rapid tolerance to the hypnotic effect of alcohol in adolescent and adult C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research, 31:105A. 30. Linsenbardt DN, Goldfarb KJ, Moore EM, Boehm II SL (2007). Adolescent and adult mice display similar responses to the ataxic effects of alcohol. Alcoholism: Clinical and Experimental Research, 31:105A. 31. Sanders, SK, Boehm II SL, Spear NE (2007) Ethanol Intake in Both DBA/2J And C57BL/6J Infant Mice Is Greater Than Water Intake. Developmental Psychobiology, 49:83. 32. Moore EM, Boehm II SL (2007) Anterior intra-ventral tegmental area microinjections of baclofen reduce alcohol intake in male C57BL/6J mice. Program No. 270.18. 2007 Abstract Viewer and Itinerary Planner, San Diego, CA: Society for Neuroscience, online. 33. Linsenbardt DN, Boehm II SL (2007) Alterations in GABAA-related gene expression are associated with locomotor sensitization to ethanol in DBA/2J mice. Program No. 909.8. 2007 Abstract Viewer and Itinerary Planner, San Diego, CA: Society for Neuroscience, online. Stephen L. Boehm II 6 34. Blackman LC, Linsenbardt DN, Darnieder L, Boehm II SL (2008) Binge-like ethanol intake alters GABA receptor subunit/subtype expression in C57BL/6J mice. Alcoholism: Clinical and Experimental Research, 32:19A. 35. Moore EM, Walsh CD, Gigante E, Cavelli A, Goldfarb KJ, Mariani J, Gross C, Zommorodian S, Linsenbardt DN DN, Boehm II SL (2008) Binge-like ethanol intake during pregnancy: Maternal Intake, maternal care, and litter weight. Alcoholism: Clinical and Experimental Research, 32:229A. 36. Moore EM, Walsh CD, Cavelli A, Gigante E, Kigel F, Goldfarb KJ, Gross C, Mariani J, Zommorodian S, Linsenbardt DN, Boehm II SL (2008) Binge-like ethanol intake during pregnancy: Behavioral impact on Offspring. Alcoholism: Clinical and Experimental Research, 32:229A. 37. Linsenbardt DN, Moore EM, Blackman L, Boehm II SL (2008) Differential sensitivity to the acute locomotor effects of GABAA drugs following ethanol-induced sensitization in DBA/2J mice. Alcoholism: Clinical and Experimental Research, 32:158A. 38. Linsenbardt DN, Walsh CD, Moore EM, Boehm II SL (2008) Bidirectional modulation of binge-like alcohol intake in C57BL/6J mice by synthetic cannabinoid agonist WIN 55-212,2. Alcoholism: Clinical and Experimental Research, 32:216A. 39. Sanders SK, Boehm II SL, Spear NE (2008) The ontogeny of ethanol consumption in DBA/2J and C57BL/6J mice. Alcoholism: Clinical and Experimental Research, 32:221A. 40. Linsenbardt DN, Walsh CD, Moore EM, Boehm II SL (2008) Synthetic Cannabinoid Antagonist SR141716A Decreases Binge-Like Alcohol Intake in C57BL/6J Mice. Program No. 257.12. 2008 Abstract Viewer and Itinerary Planner, Washington, DC: Society for Neuroscience, online. 41. Blackman LC, Moore EM, Godfarb K, Mariani J, Linsenbardt DN, Boehm II SL (2008) Ro 15-4513 alters female c57bl/6j consummatory behavior in drinking in dark model. Program No. 158.6. 2008 Abstract Viewer and Itinerary Planner, Washington, DC: Society for Neuroscience, online. 42. Moore EM, Mariani JN, Blackman LC, Linsenbardt DN, Boehm II SL (2008) Binge-like alcohol intake is increased during early adolescence in C57BL/6J and DBA2/J mice. Program No. 257.6. 2008 Abstract Viewer and Itinerary Planner, Washington, DC: Society for Neuroscience, online. 43. Linsenbardt DN, Griffin KD, Moore EM, Boehm II SL (2009) Tolerance to ethanol-induced ataxia following repeated binge-like ethanol intake using the DID model. Alcoholism: Clinical and Experimental Research, in press. 44. Blackman LC, Moore EM, Boehm II SL (2009) Acute and sensitized ethanol-induced locomotor activity in adult and adolescent mice: A comparison of the DBA/2J and C57BL/6J inbred strains. Alcoholism: Clinical and Experimental Research, in press. 45. Moore EM, Boehm II SL (2009) Ethanol-induced anxiolysis in adolescent and adult C57BL/6J and DBA/2J Mice. Alcoholism: Clinical and Experimental Research, in press. 46. Blackman LC, Boehm II SL (2009) Binge Drinking in the DID paradigm changes locomotor response to 2.0g/kg challenge of EtOH in C57Bl/6J females. 2009 Abstract Viewer and Itinerary Planner, Chicago, IL: Society for Neuroscience, submitted. 47. Linsenbardt DN, Boehm II SL (2009) Sensitization and tolerance to ethanol-induced locomotion in B6D2F2 mice. 2009 Abstract Viewer and Itinerary Planner, Chicago, IL: Society for Neuroscience, submitted. 48. Moore EM, Blackman LC, Linsenbardt DN, Boehm II SL (2009) Adolescent C57BL/6J and DBA/2J mice show differential preference to ethanol in a two bottle Drinking in the Dark procedure. 2009 Abstract Viewer and Itinerary Planner, Chicago, IL: Society for Neuroscience, submitted. Talks and Invited Presentations: Boehm II SL, Phillips TJ (2001) GABAB modulation of ethanol's locomotor stimulant effects. Invited seminar given at the University of Texas at Austin, Section of Neurobiology. Boehm II SL, Phillips TJ (2001) GABAB modulation of ethanol's locomotor stimulant effects. Invited seminar given at the University of Colorado Health Sciences Center, Department of Pharmacology. Boehm II SL, Harris RA (2003) Deletion of the fyn-kinase gene alters behavioral sensitivity to alcohol: Evidence for altered GABAA receptor function. Invited speaker at the Research Society on Alcoholism conference in Ft. Lauderdale, Florida. Boehm II SL (2003) Is alcohol sensitivity modulated by interactions between fyn-kinase and the GABAA receptor? Invited speaker at the Waggoner Center for Alcohol and Addiction Research fifth year celebration, Austin, Texas. Stephen L. Boehm II 7 Boehm II SL, Harris RA (2004) Are alcohol’s behavioral effects associated with specific GABAA receptor subunits? Invited seminar given at the University of Virginia, Department of Psychiatric Medicine. Boehm II SL, Harris RA (2004) Are alcohol’s behavioral effects associated with specific GABAA receptor subunits? Invited seminar given at Binghamton University - SUNY, Department of Psychology. Boehm II SL, Blednov YA, Ponomarev I, Harris RA (2005) From gene to behavior and back again: New perspectives on GABAA receptor subunit selectivity of alcohol actions. Invited speaker at the National Institute on Alcohol Abuse and Alcoholism Trainee Workshop, Indianapolis, Indiana. Boehm II SL (2008) Using Drinking in the Dark to investigate the neurobiological underpinnings of binge-like ethanol intake in the mouse. Invited speaker at Indiana University Purdue University Indianapolis, Department of Psychology. Grant Support: 1. Active National Institute on Alcohol Abuse and Alcoholism (K01 AA015434) Role of GABA-A alpha 1 in locomotor sensitization to ethanol Principal Investigator 9/1/05-8/31/10 (total direct costs = $750,000) Integrative Neuroscience Initiative on Alcoholism (INIA-west Pilot Project) Role of endocannabinoid receptor systems in binge-like ethanol intake Principal Investigator 9/1/07-8/31/09 (total direct costs = $67,000) National Institute on Alcohol Abuse and Alcoholism (R01 AA016789) GABAergic mechanisms in the modulation of binge-like ethanol intake in mice Principal Investigator 1/1/09-12/31/13 (total direct costs = $1,125,000) 2. Pending National Institute on Alcohol Abuse and Alcoholism (R01) Adolescent sensitivity to ethanol’s hypnotic and locomotor stimulant actions and association with binge-like ethanol preference and intake in eight inbred mouse strains Principal Investigator 12/1/08-11/30/13 (total direct costs = $1,250,000) 3. Expired National Institute on Alcohol Abuse and Alcoholism (F32 AA014455) GABA-A subunit specificity of ethanol-related behavior Principal Investigator 9/1/03-3/31/05 National Institute on Alcohol Abuse and Alcoholism (F31 AA05577) GABA-B receptor modulation of ethanol-stimulated locomotion Principal Investigator 9/1/00-8/31/01 Manuscript Reviewer for Several Peer Reviewed Journals Alcohol and Alcoholism Alcoholism: Clinical and Experimental Research American Journal of Neuropsychiatric Genetics Biochemical Pharmacology European Journal of Pharmacology Journal of Pharmacology and Experimental Therapeutics Journal of Neurochemistry Stephen L. Boehm II 8 Journal of Neuroscience Nature Protocols Neuropharmacology Neuropsychopharmacology Pharmacology Biochemistry and Behavior Physiology and Behavior Psychopharmacology Teaching Experience: General Psychology (undergraduate) – spring 2007, fall 2008 Neurochemistry (graduate) – fall 2005, fall 2007 Neurobiology of Addiction Seminar (graduate) – spring 2005 Graduate Student Advisor: Eileen Moore, 2005-present David Linsenbardt DN, 2006-present Laverne Blackman, 2007-present Student Thesis Committee Membership: Courtney Vetter – Masters Thesis entitled “Time-course of elevated intake in adolescent relative to adult rats under continuous, voluntary-access conditions” Completed fall 2006 Eric Truxell, MA – Doctoral Dissertation entitled “Assessment of ethanol reinforcement through operant and second order conditioning during infancy: An ontogenetic perspective” Completed fall 2007. Eileen Moore – Masters Thesis entitled “Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice” Completed spring 2008 Tamara Doremus-Fitzwater, MA – Doctoral Dissertation entitled “Incentive motivational processes in adolescent and adult rats: Effects of amphetamine sensitization on cue-induced craving for natural rewards” completed in fall 2008 David Linsenbardt DN – Masters Thesis entitled “Endocannabinoid modulation of binge-like alcohol intake in male C57BL/6J mice” completed fall 2008 Administrative Activities: 2009 – present – ad hoc grant reviewer, NIH/NIAAA 2008-2009 – Chair, Behavioral Neuroscience Faculty Search Committee, Binghamton University 2008-2009 – Intercollegiate Athletics Board, Binghamton University 2008-2009 – Institutional Animal Care and Use Committee, Binghamton University 2008 – Search Committee, Director of Compliance and Risk Management, Binghamton University 2006-2009 – Undergraduate Committee, Department of Psychology, Binghamton University 2007-2009 – Faculty Senate Intercollegiate Athletics Committee, Binghamton University Outreach Activities: 2007-2008 – Bridges to the Baccalaureate faculty mentor, Binghamton University, Binghamton, NY Eduardo Gigante (2007), Kevar Griffin (2008) 2006-2009 – Guest 1st, 2nd, and 3rd grade science teacher, Vestal Hills Elementary School, Vestal, NY 2005-2007 – Guest speaker on the graduate application process in experimental psychology, Psi Chi, Binghamton University, Binghamton, NY References: Dr. R. Adron Harris Waggoner Center for Alcohol and Addiction Research University of Texas at Austin 1 University Station A4800 Austin, TX 78712-0159 (512) 232-2514 harris@mail.utexas.edu Stephen L. Boehm II 9 Dr. Tamara J. Phillips Research Service (R & D 32) VA Medical Center 3701 SW Veterans Hospital Road Portland, OR 97239 (503) 220-8262 x56674 phillipt@ohsu.edu Dr. John C. Crabbe Research Service (R & D 12) VA Medical Center 3701 SW Veterans Hospital Road Portland, OR 97239 (503) 220-8262 x55298 crabbe@ohsu.edu Dr. David M. Gilliam Department of Behavioral Sciences, McKee 14 University of Northern Colorado Greeley, CO 80639-0001 (970) 351 - 2951 David.Gilliam@unco.edu Dr. Linda P. Spear Department of Psychology (Sci 4, Rm 230) Binghamton University - SUNY 4400 Vestal Parkway East Binghamton, NY 13902-6000 (607) 777-2825 lspear@binghamton.edu