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Work in the Boehm Research Lab is aimed at defining how alcoholism and binge drinking is influenced by genes and developmental factors. Alcohol-related behaviors thought to influence propensity to engage in binge-like alcohol drinking in mice are studied. We use mice of different developmental and genetic backgrounds to ask mechanistic questions about the complex relationships between brain and behavior. For example, we compare different genetic mouse models to assess age-specific sensitivity to alcohol's behavioral actions and determine how alcohol exposure during prenatal and early postnatal development influences that of adulthood. Moreover, we employ state-of-the-art techniques to study the relationships between brain and behavioral sensitivity to alcohol in mice, including site-specific microinjection into discrete brain regions and real-time PCR analysis of relative mRNA expression across brain structures to determine which neurotransmitter systems and brain structures are important modulators of alcohol-related behavior. Our hope is that such work will help elucidate the behavioral/brain mechanisms associated with alcohol behavioral sensitivity in humans and provide further insight into how those mechanisms influence (and are influenced by) binge alcohol drinking across development. Our work is supported by grants from the National Institute on Alcohol Abuse and Alcoholism and the Integrative Neuroscience Initiative on Alcoholism - West.
| Principle Investigator - | Stephen Boehm, Ph.D. - [vita] | |||||||||||||||||||
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| xxx, Ph.D. xxx, Ph.D. xxx, Ph.D. | David Linsenbardt xxx | xxx - Lab Manager xxx xxx | ||||||||||||||||||
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List of Projects
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